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Biological Activity

(Z)-Pugnac is an vastly potent inhibitor of O-GlcNAcase via both in vitro and intact cell experiments.

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Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Anifea A (mg/kg) = Anifeo B (mg/kg) multiplied by Anifea B Km
Animalo A Km

For example, to modify the dose of resveratrol used for al mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then dividel by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecuresidencia Weight 353.33
Formula C15H19N3O7
CAS Number 132489-69-1
Purity >98%

Solubility DMSO
Storage at -20°C


Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry.Perreiral M, et al. Bioorganic & medicinal chemistry. 2006 Feb 1;14(3):837-46. PMID: 16214344.

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